KMUi-Biomedicine-1: Development and preclinical qualification of novel periodontitis therapeutics for clinical use (ParoPaste) – Research into and preclinical qualification of novel periodontitis therapeutics in proof-of-concept models and regulatory preparation for clinical use
Alternative metal-binding groups in drugs for the treatment of periodontitis - AMePA
Controlled-release drug delivery systems using innovative and selective drug molecules for the treatment of bacterial infections of the periodontium – ParoStop
Profiling inhibitors of bacterial glutaminyl cyclases as drug prototypes for novel periodontal therapeutics – PInParo
Title: Effect of a bacterial glutaminyl cyclase inhibitor on multi-species biofilms.
Authors: Eick, Sigrun, Taudte, Nadine, Ramsbeck, Daniel, Magdoń, Anna, Sculean, Anton, Potempa, Jan, Buchholz, Mirko
Year of publication: 2025
Journal: Front. Oral Heal. 6, 1716625.
Link: DOI
Title: Novel small molecule targeting PgQC reduces Porphyromonas gingivalis virulence
Authors: Nadine Taudte, Linda Liebe, Nadine Jänckel, Daniel Ramsbeck, Stephan Schilling, Jan Potempa, Sigrun Eick, Mirko Buchholz
Year of publication: 2026
Journal: Front. Oral Health 7:1716188.
Link: DOI
Title: Tetrahydroimidazo[4,5-c]pyridine-Based Inhibitors of Porphyromonas gingivalis Glutaminyl Cyclase
Authors: Daniel Ramsbeck, Nadine Taudte, Nadine Jänckel, Stefanie Strich, Jens-Ulrich Rahfeld, Mirko Buchholz2
Year of publication: 2021
Journal: Pharmaceuticals 2021, 14(12). 1206.
Link: DOI
Title: Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis
Authors:
Taudte, Nadine; Linnert, Miriam; Rahfeld, Jens‑Ulrich; Piechotta, Anke; Ramsbeck, Daniel; Buchholz, Mirko; Kolenko, Petr; Parthier, Christoph; Houston, John A.; Veillard, Florian; Eick, Sigrun; Potempa, Jan; Schilling, Stephan; Demuth, Hans‑Ulrich; Stubbs, Matthew T.
Year of publication: 2021
Journal: Journal of Biological Chemistry 296, 100263.
Link: DOI
Title: Effect of a bacterial glutaminyl cyclase inhibitor on multi-species biofilms.
Authors: Eick, Sigrun, Taudte, Nadine, Ramsbeck, Daniel, Magdoń, Anna, Sculean, Anton, Potempa, Jan, Buchholz, Mirko
Year of publication: 2025
Journal: Front. Oral Heal. 6, 1716625.
Link: DOI
Title: Novel small molecule targeting PgQC reduces Porphyromonas gingivalis virulence
Authors: Nadine Taudte, Linda Liebe, Nadine Jänckel, Daniel Ramsbeck, Stephan Schilling, Jan Potempa, Sigrun Eick, Mirko Buchholz
Year of publication: 2026
Journal: Front. Oral Health 7:1716188.
Link: DOI
Title: Tetrahydroimidazo[4,5-c]pyridine-Based Inhibitors of Porphyromonas gingivalis Glutaminyl Cyclase
Authors: Daniel Ramsbeck, Nadine Taudte, Nadine Jänckel, Stefanie Strich, Jens-Ulrich Rahfeld, Mirko Buchholz2
Year of publication: 2021
Journal: Pharmaceuticals 2021, 14(12). 1206.
Link: DOI
Title: Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis
Authors:
Taudte, Nadine; Linnert, Miriam; Rahfeld, Jens‑Ulrich; Piechotta, Anke; Ramsbeck, Daniel; Buchholz, Mirko; Kolenko, Petr; Parthier, Christoph; Houston, John A.; Veillard, Florian; Eick, Sigrun; Potempa, Jan; Schilling, Stephan; Demuth, Hans‑Ulrich; Stubbs, Matthew T.
Year of publication: 2021
Journal: Journal of Biological Chemistry 296, 100263.
Link: DOI
PerioTrap Pharmaceuticals GmbH
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